Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Protein Organization

Protein Organization

Protein and Protein Structures

Protein and Protein Structures

Protein-Protein Interfaces

Protein-Protein Interfaces

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

First human decedent model of orthotopic multi-organ xenotransplantation: Whole liver and bilateral kidneys from a six-gene-edited pig.

Med (New York, N.Y.)·2026

Same author

Accurate prediction of cohesin and RNA Polymerase II-associated chromatin interactions using convolutional neural networks.

Nucleic acids research·2026

Same author

Autonomous Robot-Assisted Video Capture in Open Cardiac Surgery: Surgical Field Detection and Obstacle-Aware Viewpoint Planning via CHELS.

The international journal of medical robotics + computer assisted surgery : MRCAS·2026

Same author

Introduction to bioimaging-based spatial multi-omic novel methods.

Quantitative biology (Beijing, China)·2026

Same author

Single-cell analyses reveal impaired type B spermatogonia differentiation and meiotic entry in C-Nap1-null testes.

Quantitative biology (Beijing, China)·2026

Same author

Dialog between artificial intelligence & natural intelligence.

Quantitative biology (Beijing, China)·2026

Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026

Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026

Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026

Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026

Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026

Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 2, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Web3DMol: interactive protein structure visualization based on WebGL.

Maoxiang Shi¹, Juntao Gao², Michael Q Zhang^2,3

¹Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

Nucleic Acids Research

|May 9, 2017

Summary

This summary is machine-generated.

Web3DMol is a new web application for visualizing protein structures in 3D directly in web browsers. It offers interactive manipulation and analysis tools for researchers studying protein structures.

More Related Videos

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

Author Spotlight: Insights into the Analysis of Human Interaction with 3D Virtual Objects

Author Spotlight: Insights into the Analysis of Human Interaction with 3D Virtual Objects

Published on: October 18, 2024

Related Experiment Videos

Last Updated: Mar 2, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

Author Spotlight: Insights into the Analysis of Human Interaction with 3D Virtual Objects

Author Spotlight: Insights into the Analysis of Human Interaction with 3D Virtual Objects

Published on: October 18, 2024

Area of Science:

Biochemistry
Structural Biology
Bioinformatics

Background:

Increasing development of web-based databases and tools for protein research.
Widespread need for accessible 3D protein structure visualization in web browsers.

Purpose of the Study:

Introduce Web3DMol, a novel web application for interactive 3D protein structure visualization.
Provide researchers with an intuitive tool for exploring protein structures directly within web browsers.

Main Methods:

Developed Web3DMol as a web application utilizing modern browser technologies.
Enabled users to input PDB identification codes or local PDB files for visualization.
Integrated interactive manipulation features and analysis tools.

Main Results:

Web3DMol successfully displays and allows interactive manipulation of 3D protein structures.
Included features such as sequence plot, fragment segmentation, measure tool, and meta-information display.
Provided easy-to-use APIs for developers to extend functionality.

Conclusions:

Web3DMol addresses the need for accessible web-based protein structure visualization.
The tool enhances understanding of protein structures through interactive features and analysis.
Web3DMol is freely available with source code under the MIT license for broad adoption.