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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Cardiac Structural and Functional Changes Evaluated by Transthoracic and Tissue Doppler Echocardiography in Adult

Mojdeh Dabirian1, Ghasem Janbabaei2, Hossein Karami3

  • 1Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Acta Informatica Medica : AIM : Journal of the Society for Medical Informatics of Bosnia & Herzegovina : Casopis Drustva Za Medicinsku Informatiku Bih
|May 10, 2017
PubMed

Insights

Sickle cell disease (SCD) patients show elevated early and late diastolic velocity waves, suggesting potential future cardiac issues. Echocardiography did not reveal significant systolic or diastolic dysfunction compared to healthy individuals.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Imaging

Background:

  • Sickle cell disease (SCD) is a common inherited blood disorder associated with significant mortality, particularly in adults.
  • Left ventricular diastolic dysfunction and pulmonary hypertension are serious complications in SCD patients.
  • Echocardiography, including Tissue Doppler Echocardiography (TDE) and transthoracic echocardiography (TTE), are valuable tools for assessing cardiac risk in SCD.

Purpose of the Study:

  • To evaluate cardiac structure and function in adult sickle cell anemia patients.
  • To compare echocardiographic findings in SCD patients with those of healthy controls.

Main Methods:

  • The study included 30 adult SCD patients (age 18-40) and a control group.
  • Left and right ventricular functions were assessed using M-mode, 2D echocardiography, TRJV, and TDE-derived myocardial velocity measurements.
  • Data from SCD patients were compared to healthy controls.

Main Results:

  • SCD patients exhibited significantly higher E and E' waves of left ventricle inflow compared to the control group (p<0.03 and p<0.01).
  • No significant difference was found in the E/E' ratio between SCD patients and controls.
  • Significant differences were observed in peak early and late LV diastolic velocities between the groups.

Conclusions:

  • Tissue Doppler Echocardiography did not reveal significant differences in LV systolic and diastolic function between SCD patients and healthy subjects.
  • Elevated E and E' waves in SCD patients may signal future progression towards cardiac disorders and pulmonary hypertension.
  • Early detection and monitoring of cardiac function in SCD are crucial.

Keywords:
Sickle cell diseaseTissue Doppler echocardiographyTransthoracic echocardiographyVentricular functionVentricular structure

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