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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

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Published on: July 13, 2019

Detection of Human Polyomavirus DNA Using the Genome Profiling Method.

Yuka Tanaka¹, Rieko Hirata¹, Kyohei Mashita¹

¹Department of Forensic Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Sciences, 465 Kajii-cho Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

The Open Virology Journal

|May 10, 2017

Summary

Genome profiling (GP) can identify different viral species, even from clinical samples. This simple, economical method shows promise for future forensic and diagnostic applications.

Keywords:

BK virus Genome profiling method JC virus random PCR temperature gradient gel electrophoresis urine

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Merkel Cell Polyomavirus Infection and Detection

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Merkel Cell Polyomavirus Infection and Detection

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Area of Science:

Forensic Medicine
Bioengineering
Virology

Background:

Identifying viral infections pre-autopsy in forensic medicine is challenging.
Current methods may lack specificity or require extensive resources.

Purpose of the Study:

To evaluate the genome profiling (GP) method for identifying distinct viral species.
To assess GP's utility in forensic and diagnostic virology.

Main Methods:

Compared conventional genome sequencing with random PCR-based GP.
Utilized JC and BK viruses (two species in the same family) for analysis.
Employed cluster analysis for GP results and phylogenetic analysis for sequencing.

Main Results:

Successfully distinguished between JC and BK viral species using GP.
Detected JC virus from a clinical sample, demonstrating practical applicability.
GP method showed comparable results to conventional sequencing in species identification.

Conclusions:

Genome profiling (GP) offers a potential simple, economical, and reagent-free approach for viral species detection.
GP method shows promise as a future tool in forensic medicine and diagnostics.
Further trials are needed, but GP could simplify viral identification processes.