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Related Experiment Video

Updated: Mar 2, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

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Gastrointestinal Stromal Tumor Induced Hypercalcemia.

Aram Barbaryan¹, Stefania Bailuc², Padma Poddutoori¹

¹Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.

Case Reports in Oncological Medicine

|May 10, 2017

Summary

A rare case of hypercalcemia caused by 1,25-dihydroxyvitamin D3 overproduction in metastatic gastrointestinal stromal tumor is presented. This endocrine emergency showed a temporary response to imatinib treatment.

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Area of Science:

Endocrinology
Oncology

Background:

Hypercalcemia is a frequent complication in cancer patients, impacting up to 44% of this population.
1,25-dihydroxyvitamin D3-mediated hypercalcemia is a rare endocrine emergency mechanism in cancer.
Solid organ neoplasms rarely cause hypercalcemia via 1,25-dihydroxyvitamin D3 production.

Observation:

A 77-year-old female presented with hypercalcemia.
Metastatic gastrointestinal stromal tumor was diagnosed as the underlying cause.
This represents only the sixth reported case of gastrointestinal stromal tumor associated with hypercalcemia.

Findings:

The patient's hypercalcemia was attributed to tumor cell overproduction of 1,25-dihydroxyvitamin D3.
Imatinib therapy initially normalized serum calcium levels.
Discontinuation of imatinib due to fluid retention led to relapsed, treatment-resistant hypercalcemia.

Implications:

This case highlights a rare mechanism of cancer-related hypercalcemia.
It underscores the importance of considering vitamin D-mediated hypercalcemia in solid tumors.
The findings suggest potential challenges in managing this specific endocrine emergency.