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In vitro low frequency electromagnetic field effect on fast axonal transport
M Zborowski1, M Atkinson, J J Lewandowski
1Department of Artificial Organs, Cleveland Clinic Foundation, Ohio 44106.
ASAIO Transactions
|July 1, 1988
Summary
Low frequency electromagnetic fields significantly impacted fast axonal transport in rat nerves. This finding suggests potential for electromagnetic fields in developing future neuroprosthetics.
Area of Science:
- Neuroscience
- Biophysics
Background:
- Fast axonal transport is crucial for neuronal function.
- Neuroprosthetic applications require precise control over neural activity.
Purpose of the Study:
- To investigate the effects of low-frequency electromagnetic fields (EMFs) on fast axonal transport.
- To assess the potential of EMFs for neuroprosthetic applications.
Main Methods:
- In vitro study using rat sciatic nerve preparations.
- Exposure to 15 and 50 Hz pulsed magnetic fields (4.4 and 8.8 mT).
- Video enhanced differential interference contrast microscopy to observe organelle transport.
Main Results:
- Significant cessation of retrograde fast organelle transport observed in myelinated axons.
- Transport disruption occurred within 10 minutes of EMF exposure.
- Calculated induced eddy current density was approximately 40 microA/cm2.
Conclusions:
- Low-frequency EMFs can effectively modulate fast axonal transport.
- These findings support the potential use of EMFs in noninvasive neuroprosthetic devices.
- Further research may lead to novel ways to interface with the nervous system.