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Related Experiment Video

Updated: Mar 2, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Oxytocin and Migraine Headache.

Alexander Tzabazis¹, Shashi Kori², Jordan Mechanic²

¹Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA.

|May 10, 2017

Summary

Intranasal oxytocin shows promise for migraine treatment, particularly in reducing headache frequency. Further research is recommended for its development as a migraine prophylactic therapy.

Keywords:

CGRP dura matter oxytocin prophylactic rat models trigeminal

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Area of Science:

Neuroscience
Pharmacology

Background:

Migraine headache is a complex neurological condition.
Oxytocin is a hormone with potential therapeutic applications.

Purpose of the Study:

To review scientific results and rationale for using intranasal oxytocin for migraine treatment.
To explore the efficacy of intranasal oxytocin in reducing migraine frequency and pain.

Main Methods:

Preclinical in vitro and in vivo studies on trigeminal neurons and rat models.
Clinical studies including episodic and chronic migraineurs with varying dosing regimens.
A multicountry double-blind, placebo-controlled trial.

Main Results:

Oxytocin inhibits trigeminal neurons and CGRP release.
Inflammation upregulates oxytocin receptors on trigeminal neurons.
Clinical studies showed reduced headache frequency and pain, with some trials not meeting primary endpoints due to high placebo rates.

Conclusions:

Intranasal oxytocin demonstrates potential for migraine prophylaxis.
Further development is warranted despite mixed clinical trial outcomes.
The role of inflammation in treatment efficacy requires continued investigation.