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KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival

H Ohguchi1, T Harada1, M Sagawa1

  • 1Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Leukemia
|May 11, 2017
PubMed
Summary

KDM6B promotes multiple myeloma (MM) cell growth by activating NF-κB and MAPK signaling pathways, independent of its demethylase activity. Targeting KDM6B offers a novel therapeutic strategy for MM treatment.

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