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A generic label-free microfluidic microobject sorter using a magnetic elastic diverter.

Jiachen Zhang1, Onaizah Onaizah1, Amir Sadri2

  • 1Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario, M5S 3G8, Canada.

Biomedical Microdevices
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Summary

This study introduces a novel label-free microfluidic cell sorter using a magnetically actuated elastic diverter. This innovative device offers flexible, non-contact sorting for biological samples, enhancing safety and integration possibilities.

Keywords:
Lab-on-a-chipMagnetic actuationMagnetic elastic compositeMechanical sortingMicrofluidic cell sorter

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Cell Sorting

Background:

  • Cell sorters are crucial for biological and medical research, including disease diagnosis and therapy.
  • Existing magnetic sorters often require specific sample properties (magnetic or coated).
  • Sample contamination and damage are risks in current cell sorting methods.

Purpose of the Study:

  • To develop a versatile, label-free microfluidic cell sorter.
  • To enable flexible sorting criteria without modifying target microobjects.
  • To enhance safety and integration in lab-on-a-chip systems.

Main Methods:

  • A microfluidic sorter with a downstream-pointing magnetic elastic diverter was designed.
  • The diverter is wirelessly deformed by an external magnetic field, creating a fluid vortex for sorting.
  • Off-chip electromagnetic coils generate the magnetic field, ensuring no on-chip components are needed.

Main Results:

  • The diverter sorts microobjects (e.g., cells) without direct contact, minimizing contamination and damage.
  • Demonstrated parallel and independent control of two diverters for increased throughput or cascaded sorting.
  • Achieved a 96.68% raw success rate in sorting microbeads.

Conclusions:

  • The proposed label-free microfluidic sorter offers a flexible, safe, and cost-effective solution.
  • Its simple structure and integration capabilities make it suitable for diverse lab-on-a-chip applications.
  • This technology presents a promising tool for academic and industrial sorting needs.