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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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Chirality as a tool for function in porous organic cages.
T Hasell1, M A Little1, S Y Chong1
1Univ Liverpool, Dept Chem, Crown St, Liverpool L69 7ZD, Merseyside, England, UK. t.hasell@liverpool.ac.uk aicooper@liverpool.ac.uk.
Nanoscale
|May 11, 2017
Summary
Researchers developed methods to create chiral porous organic cages, overcoming challenges in solid-state assembly. This work enables new routes for chiral cage synthesis and modification, advancing materials science.
Area of Science:
- Materials Science
- Supramolecular Chemistry
- Crystallography
Background:
- Controlling solid-state assembly of porous organic cages (POCs) is complex compared to extended frameworks like metal-organic frameworks (MOFs).
- Chiral recognition offers a strategy for precise control over cage assembly.
Purpose of the Study:
- Investigate chiral analogues of previously studied racemic POCs.
- Develop scalable methods for producing chiral POCs.
- Explore the modular assembly and properties of chiral POCs.
Main Methods:
- Synthesis of chiral POCs from chiral precursors.
- Separation of racemic POCs via co-crystallization with a second chiral cage.
- Isoreticular co-crystallization to modify porosity.
- Experimental and computational modeling to study chirality interconversion.
Main Results:
- Demonstrated direct synthesis of chiral cages from chiral precursors.
- Established a method for producing chiral cages from achiral precursors via co-crystallization.
- Achieved modular, isoreticular assembly of chiral cages, tuning porosity.
- Identified solvent-dependent crystal packing and chirality interconversion in solution.
Conclusions:
- Chiral recognition provides effective control over solid-state assembly of POCs.
- New synthetic routes to chiral POCs are now available, including those from achiral starting materials.
- Understanding and controlling chirality interconversion is crucial for POC applications.
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