Related Experiment Video
Updated: Mar 2, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
A pH-Responsive DNAsome from the Self-Assembly of DNA-Phenyleneethynylene Hybrid Amphiphile
Shine K Albert1, Murali Golla1, Hari Veera Prasad Thelu1
1School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram (IISER-TVM), CET campus, Trivandrum-, 695016, India.
Abstract:
A pH-responsive DNAsome derived from the amphiphilicity-driven self-assembly of DNA amphiphile containing C-rich DNA sequence is reported. The acidification of DNAsome induces a structural change of C-rich DNA from random coil to an i-motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network. The encapsulation of a hydrophobic guest into the membrane of DNAsome and its pH-triggered release upon acidification of DNAsome is also demonstrated.
Related Concept Videos
Cooperative Binding of Transcription Regulators
DNA Bacteriophages
Nucleic Acid Structure
DNA Structure
DNA...

