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Related Concept Videos

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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An Ex vivo Culture System to Study Thyroid Development
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Thyroid Function during Early Life and Dental Development.

S Vucic1,2, T I M Korevaar1,3, B Dhamo1,2

  • 11 The Generation R Study Group, Erasmus University Medical Centre, Rotterdam, the Netherlands.

Journal of Dental Research
|May 11, 2017
PubMed
Summary
This summary is machine-generated.

Thyroid function in early life, specifically thyroid-stimulating hormone (TSH) levels and maternal thyroid peroxidase antibodies (TPOAb), is linked to children's dental development. Higher TSH or TPOAb presence may be associated with poorer dental development outcomes.

Keywords:
endocrinologyepidemiologygrowth/developmentmineralized tissue developmentradiographytooth development

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Area of Science:

  • Endocrinology and Dental Development
  • Pediatric Health and Oral Development

Background:

  • Thyroid hormone imbalances (hypo- and hyperthyroidism) are known to affect dental development in children.
  • The impact of normal or subclinical thyroid function variations on dental tissues in healthy children remains unclear.
  • Understanding early-life thyroid function's role in dental development is crucial for pediatric oral health.

Purpose of the Study:

  • To investigate the association between thyroid function from fetal life to early childhood and dental development at school age.
  • To explore the relationship between maternal and offspring thyroid function and children's dental development.
  • To determine if thyroid peroxidase antibody (TPOAb) status in mothers influences offspring dental development.

Main Methods:

  • Utilized data from the Generation R Study, a population-based cohort in the Netherlands.
  • Measured maternal thyroid function (TSH, FT4, TPOAb) in early pregnancy.
  • Assessed offspring thyroid function (TSH, FT4) in cord blood and at age 6, and dental development via panoramic radiographs at age 9.
  • Employed multivariable linear regression analysis on a large sample size (2,387–2,706 subjects).

Main Results:

  • Inverse association found between cord blood and early childhood TSH concentrations and dental development.
  • No significant association between maternal thyroid function during pregnancy and children's dental development.
  • Children of TPOAb-positive mothers exhibited a significantly lower dental development score compared to those of TPOAb-negative mothers.

Conclusions:

  • Thyroid hormone plays a role in tooth maturation from early life stages.
  • Offspring thyroid function (TSH) in infancy and early childhood, and maternal TPOAb status, are associated with dental development.
  • Further research may elucidate specific mechanisms linking thyroid function to dental hard tissue development.