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[Beta thalassaemia: a surprising radiological image]
S Ombashi1, M Wevers1, J C G Wagemans1
1From the Department of Oral Diseases, Maxillofacial Surgery/Special Dentistry Outpatient Clinic at Erasmus Medical Centre, Rotterdam.
The aetiology of thalassaemia lies in a defect in the synthesis of 1 of the 2 chains, alpha or beta, of the haemoglobin molecule. This failure primarily results in haemolytic anaemia, which is the main clinical feature of the disorder. As a consequence of this haemolysis, erythropoiesis is stimulated, which in turn leads to morphological changes in the bone and hypertrophy of other organs. Radiographic findings reveal a decrease in cortical thickness accompanied by trabecular reduction in the bone, including the facial bones. Commonly, no local treatment is required in the field of maxillofacial or dental care.
The aetiology of thalassaemia lies in a defect in the synthesis of 1 of the 2 chains, alpha or beta, of the haemoglobin molecule. This failure primarily results in haemolytic anaemia, which is the main clinical feature of the disorder. As a consequence of this haemolysis, erythropoiesis is stimulated, which in turn leads to morphological changes in the bone and hypertrophy of other organs. Radiographic findings reveal a decrease in cortical thickness accompanied by trabecular reduction in the bone, including the facial bones. Commonly, no local treatment is required in the field of maxillofacial or dental care.
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