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Tailoring stimuli-responsive delivery system driven by metal-ligand coordination bonding
Hongshan Liang1,2,3, Bin Zhou4, Yun He1,2,3
1College of Food Science and Technology, Huazhong Agricultural University.
International Journal of Nanomedicine
|May 12, 2017
Summary
A novel metal-tannic acid nanoparticle system offers pH-responsive drug delivery. This stable system shows controlled release and high cytotoxicity against cancer cells, demonstrating potential for advanced drug delivery applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Zein/carboxymethyl chitosan (CMCS) nanoparticles (NPs) are established drug/nutrient delivery vehicles.
- Coordination bonding systems offer tunable release mechanisms.
- pH-responsive materials are crucial for targeted drug delivery.
Purpose of the Study:
- To investigate a novel metal-tannic acid (TA) coordination bonding system on zein/CMCS NPs for pH-responsive drug delivery.
- To evaluate the stability, drug release, and cytotoxicity of the developed NPs.
- To assess the potential of this platform for targeted cancer therapy.
Main Methods:
- Fabrication of zein/CMCS NPs coated with metal-TA coordination bonds.
- Investigation of pH-responsive drug release using doxorubicin hydrochloride (DOX).
- In vitro stability, cytotoxicity assays (HepG2 cells), confocal laser scanning microscopy (CLSM), and flow cytometry for uptake studies.
Main Results:
- The zein/CMCS-TA/metal NPs exhibited good stability in cell culture medium.
- Significant and sensitive drug release was observed under mild acidic conditions due to coordination bond cleavage.
- DOX-loaded NPs demonstrated potent cytotoxicity against HepG2 cells and efficient cellular uptake.
Conclusions:
- The developed metal-TA-coated zein/CMCS NPs represent a versatile and potent platform for pH-responsive drug delivery.
- The system's stability and tunable release characteristics make it promising for targeted therapies.
- This novel coordination bonding system holds significant potential for advancing drug delivery applications.
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