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Multiple cutaneous granular cell tumors in childhood
J R Kyler1, S E Krause, S B Mallory
1Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock.
Southern Medical Journal
|December 1, 1988
Summary
Two children with multiple cutaneous granular cell tumors (GCT) were treated with surgical excision. Specific stains aided in tumor margin demarcation, supporting a neural origin for these rare pediatric skin tumors.
Area of Science:
- Dermatology
- Pediatric Oncology
- Surgical Pathology
Background:
- Multiple cutaneous granular cell tumors (GCT) are rare, particularly in pediatric cases, with only 18 previously reported.
- Understanding the histogenesis of GCT remains a challenge, with ongoing debate regarding their cellular origin.
Observation:
- Two pediatric patients presented with multiple cutaneous granular cell tumors.
- Surgical excision was performed on three rapidly growing or symptomatic lesions in these patients.
Findings:
- Specific stains for enolase and S-100 protein effectively demarcated tumor margins post-excision.
- The findings support the theory that GCTs originate from Schwann cells or neural precursor cells.
Implications:
- Surgical excision is the primary treatment for symptomatic or rapidly growing GCTs.
- Immunohistochemical staining is crucial for achieving clear margins in GCT resections.
- Further research into the neural origins of GCTs is warranted.