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Related Experiment Video

Updated: Mar 2, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
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Modified ALPPS procedures: more safety through less invasive surgery.

Kuniya Tanaka1

  • 1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 299-0111, Japan. U17-92TS@med.teikyo-u.ac.jp.

Langenbeck'S Archives of Surgery
|May 12, 2017
PubMed
Summary

Modifications to associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) aim to improve safety for advanced liver tumors. Further research is needed to confirm the benefits and risks of these modified procedures.

Keywords:
ALPPSModified ALPPSStaged hepatectomy

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Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Gastroenterology

Background:

  • Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a technique for advanced liver tumors.
  • High morbidity and mortality rates associated with the original ALPPS procedure necessitate safety improvements.

Purpose of the Study:

  • To review modifications to the ALPPS procedure.
  • To clarify the contributions of these modifications to patient safety and their clinical relevance.

Main Methods:

  • Review of reported modifications to the original ALPPS procedure.
  • Analysis of modifications aimed at reducing adhesions, preventing tumor spread, and minimizing surgical invasiveness.

Main Results:

  • Various modifications aim to enhance safety by reducing adhesions, preventing tumor spread, and avoiding devascularization during liver splitting.
  • These modifications seek to decrease the invasiveness and severity of the surgical procedure.
  • Despite modifications, a lack of statistically significant outcome comparisons persists.

Conclusions:

  • Prospective controlled studies are required to standardize modified ALPPS procedures.
  • Further research into liver regeneration mechanisms, functional recovery, and histopathologic changes during ALPPS is essential for evaluating modifications.