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Updated: Mar 2, 2026

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells
Published on: April 21, 2021
[The advances in research on precisely inducing retinal ganglion cells from stem cells]
1Zhongshan Ophthalmic Centre, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, China.
Abstract:
The injury and repair of retinal neurons is a common scientific problem in the occurrence, development and prognosis of neuronal visual impairment. Transplant of retinal ganglion cells (RGCs) differentiated from stem cells opens a new avenue for treatment of glaucoma and optic neuronal degenerative diseases. For the goal to explore the optimal method for RGCs replacement, this review summarizes the current information regarding the classification and application of stem cells, the growth characteristics of RGCs and the precise methods to induce RGCs, and discusses some important issues that need resolving and are related to RGCs transplantation. It is hoped that this article will provide useful theoretical basis for the research of this field. (Chin J Ophthalmol, 2017, 53: 381-385).

