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Fungal Anticancer Metabolites: Synthesis Towards Drug Discovery
Margherita Barbero1, Emma Artuso1, Cristina Prandi1
1Department of Chemistry, University Degli Studi di Torino, via P. Giuria 7-10125 Torino, Italy.
Current Medicinal Chemistry
|May 13, 2017
Summary
Total synthesis of fungal metabolites offers a viable route to novel anticancer compounds. This review highlights innovative synthetic procedures crucial for developing these fungal derivatives into future drugs.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Organic Synthesis
Background:
- Fungi are a rich source of therapeutic compounds, particularly novel anticancer agents.
- Isolation from natural sources is often challenging, making total synthesis a key alternative.
- Natural product synthesis aids in discovering new biologically active compounds and developing innovative synthetic methodologies.
Purpose of the Study:
- To review the anticancer potential of fungal metabolites.
- To highlight the role of total synthesis in accessing these compounds.
- To assess the feasibility of innovative synthetic procedures for drug development.
Main Methods:
- Comprehensive literature search using chemical databases (SciFinder, Reaxys).
- Screening of literature focusing on biological activity and synthetic procedures.
- Classification of compounds based on chemical structure.
Main Results:
- Identified promising fungal metabolites with anticancer properties.
- Evaluated the synthetic feasibility of these compounds for drug development.
- Classified compounds by their chemical structures.
Conclusions:
- Total synthesis is a crucial strategy for obtaining fungal anticancer metabolites.
- Innovative synthetic procedures are feasible and facilitate drug development.
- This review is the first to focus on the total synthesis of active fungal metabolites, showcasing its potential.
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