Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Maxam-Gilbert Sequencing

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...

Gene Duplication and Divergence

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Apollo 3: Multi-Species Genome Curation.

bioRxiv : the preprint server for biology·2026

Same author

Insertions, deletions, and exchangeable couplings: a Dirichlet process over TKF92 domains and sites.

bioRxiv : the preprint server for biology·2026

Same author

Nested birth-death processes are competitive with parameter-heavy neural networks as time-dependent models of protein evolution.

bioRxiv : the preprint server for biology·2026

Same author

Setting up JBrowse 2 for Visualizing Genome Synteny.

Current protocols·2025

Same author

Selective State Space Models Outperform Transformers at Predicting RNA-Seq Read Coverage.

bioRxiv : the preprint server for biology·2025

Same author

Insertions and Deletions: Computational Methods, Evolutionary Dynamics, and Biological Applications.

Molecular biology and evolution·2024

Same journal

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026

Same journal

NAP: an open source pipeline for cross-domain microbiome profiling using Nanopore sequencing-derived amplicon data.

BMC bioinformatics·2026

Same journal

SurvGME: an R package for survival analysis with graphical and measurement error models.

BMC bioinformatics·2026

Same journal

SimMapNet: a Bayesian framework for gene regulatory network inference using gene ontology similarities as external hint.

BMC bioinformatics·2026

Same journal

Dual channel drug-drug interactions extraction based on cross attention.

BMC bioinformatics·2026

Same journal

FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins.

BMC bioinformatics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 2, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

Solving the master equation for Indels.

¹Dept of Bioengineering, University of California, Berkeley, 94720, USA. ihh@berkeley.edu.

BMC Bioinformatics

|May 13, 2017

Summary

This summary is machine-generated.

Researchers are advancing time-dependent evolutionary models for insertion-deletion (indel) events in sequence alignment and phylogenetics. Recent progress shows promise for both approximate and rigorous methods in analyzing evolutionary relationships.

Area of Science:

Computational Biology
Bioinformatics
Evolutionary Biology

Background:

Developing time-dependent evolutionary models for insertion-deletion (indel) events remains a challenge in sequence alignment and phylogenetics.

Keywords:

Alignment Indels Phylogenetics

More Related Videos

Indel Detection following CRISPR/Cas9 Mutagenesis using High-resolution Melt Analysis in the Mosquito Aedes aegypti

Indel Detection following CRISPR/Cas9 Mutagenesis using High-resolution Melt Analysis in the Mosquito Aedes aegypti

Published on: September 10, 2021

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

Published on: December 21, 2021

Related Experiment Videos

Last Updated: Mar 2, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

Indel Detection following CRISPR/Cas9 Mutagenesis using High-resolution Melt Analysis in the Mosquito Aedes aegypti

Indel Detection following CRISPR/Cas9 Mutagenesis using High-resolution Melt Analysis in the Mosquito Aedes aegypti

Published on: September 10, 2021

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

Published on: December 21, 2021

Existing models for substitution events are more tractable than those for indels.