Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.9K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

2.0K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A response to therapy for COPD with dupilumab.

The Lancet. Respiratory medicine·2025
Same author

Is Disease Stability an Attainable Chronic Obstructive Pulmonary Disease Treatment Goal?

American journal of respiratory and critical care medicine·2024
Same author

Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial.

The Lancet. Respiratory medicine·2024
Same author

GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD.

The European respiratory journal·2024
Same author

The Emerging Role of Alarmin-Targeting Biologics in the Treatment of Patients With COPD.

Chest·2024
Same author

Reply to Ariel and Suissa and to Calzetta and Rogliani.

American journal of respiratory and critical care medicine·2024
Same journal

Real-time algorithm-driven ventilation feedback to improve lung-protective ventilation in patients with ARDS (REALVENT-study): study protocol for a multicentre randomised controlled trial.

Respiratory research·2026
Same journal

Identification and functional validation of lactylation-related hub genes in idiopathic pulmonary fibrosis based on multi-omics analysis.

Respiratory research·2026
Same journal

NSUN2-mediated m5C modification of E2F1 promotes lung adenocarcinoma progression via the RAD54L signaling axis.

Respiratory research·2026
Same journal

Direct visualisation and measurement of lung microstructure reveal insights into extracellular matrix dysregulation in COPD.

Respiratory research·2026
Same journal

Proteo-metabolomic insights into the progression of chronic obstructive pulmonary disease and lung function decline.

Respiratory research·2026
Same journal

Lung ultrasound feature tracking to quantify regional lung strain in mechanically ventilated pigs.

Respiratory research·2026
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
09:41

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

14.0K

COPD monocytes demonstrate impaired migratory ability.

Arjun K Ravi1,2, Jonathan Plumb3, Rosemary Gaskell3

  • 1NIHR Respiratory and Allergy Clinical Research Facility, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, University of Manchester, Manchester, UK. ARavi@meu.org.uk.

Respiratory Research
|May 13, 2017
PubMed
Summary
This summary is machine-generated.

Chronic obstructive pulmonary disease (COPD) monocytes exhibit reduced migration despite higher CCR5 receptor expression. Increased lung macrophages in COPD may result from delayed cell death, not just recruitment.

Keywords:
CCR5COPDChemotaxisInterleukin-6Monocytes

More Related Videos

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro
09:16

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

7.6K
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

10.2K

Related Experiment Videos

Last Updated: Mar 2, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
09:41

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

14.0K
Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro
09:16

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

7.6K
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

10.2K

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Cell Biology

Background:

  • Increased lung macrophage numbers in Chronic Obstructive Pulmonary Disease (COPD) may stem from enhanced blood monocyte recruitment.
  • Chemokine receptor 5 (CCR5) is a key monocyte receptor regulated by interleukin-6 (IL-6), with elevated CCR5 ligand concentrations observed in COPD lungs.

Purpose of the Study:

  • To investigate the mechanisms of monocyte recruitment to the lungs in COPD.
  • To elucidate the specific role of CCR5 signaling in COPD pathogenesis.

Main Methods:

  • Study involved 91 COPD patients, 29 smokers, and 37 non-smokers undergoing sputum induction and plasma sampling.
  • Monocyte characterization, migration assays, quantitative PCR, and immunohistochemistry were performed on lung tissue.

Main Results:

  • COPD patients showed increased plasma IL-6 and soluble IL-6 receptor (sIL-6R) levels.
  • COPD monocytes exhibited higher CCR5 expression but impaired migration towards sputum supernatant compared to non-smokers.
  • Pulmonary microvessel monocyte recruitment was reduced in COPD, and alveolar macrophages showed delayed apoptosis (BCL2 expression).

Conclusions:

  • COPD monocytes display reduced migratory capacity despite elevated CCR5 expression.
  • Increased lung macrophage populations in COPD may be attributed to delayed apoptosis rather than solely increased recruitment.