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Updated: Mar 2, 2026

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
Published on: October 18, 2011
Alzheimer's disease, dementia, and stem cell therapy
Thomas Duncan1, Michael Valenzuela2
1Regenerative Neuroscience Group, Brain and Mind Centre & Sydney Medical School, University of Sydney, Sydney, NSW, 2050, Australia.
Abstract:
Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.
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