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Koh Yiin Hong1, Alexandre G Brolo1

  • 1Department of Chemistry, University of Victoria, Victoria, BC V8P 5C2, Canada.

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|May 13, 2017
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Summary

Researchers developed a simple, high-throughput method to create metallic gratings for surface-enhanced Raman scattering (SERS) on lab-on-chip devices. These nanostructured gold microarrays enable sensitive detection of contaminants in environmental analysis.

Keywords:
Environmental analysisLab-on-chipMicroarraysNanogratingsQuinolonesSERSSurface-enhanced Raman scattering

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Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Materials Science

Background:

  • Surface-enhanced Raman scattering (SERS) and lab-on-chip technologies offer powerful analytical capabilities.
  • Surface plasmon (SP) excitation on metallic nanostructures is crucial for SERS.
  • Developing efficient and reproducible methods for creating SERS-active substrates is essential for real-world applications.

Purpose of the Study:

  • To demonstrate a versatile procedure for fabricating large-area and microarray metallic gratings for SP excitation and SERS.
  • To explore the use of polarization anisotropy for eliminating spectral interferences.
  • To integrate nanostructured gold microarrays onto a chip for environmental SERS detection.

Main Methods:

  • Laser interference lithography (LIL), combined with laser photolithography (LPL), was used for grating fabrication.
  • Fabrication achieved high throughput and reproducibility with <5% geometrical variation.
  • Nanostructured gold microarrays were integrated with a low-cost fluidic system using epoxy membranes.

Main Results:

  • Successfully fabricated large-area and microarray metallic gratings supporting SP excitation.
  • Demonstrated the use of polarization anisotropy to suppress background noise in SERS.
  • Achieved SERS detection of ppm-levels of 8-quinolinol in aquatic systems using the integrated chip.

Conclusions:

  • The developed procedure is suitable for generating simple, integrated microarrays for SERS.
  • This approach facilitates SERS applications in environmental analysis.
  • The method offers a reproducible and high-throughput route to SERS-active nanostructures.