Biomolecular NMR: Past and future

Area of Science:

• Biochemistry
• Biophysics
• Structural Biology

Background:

• The authors recount their >90 years of collective experience in biomolecular Nuclear Magnetic Resonance (NMR).
• Their narrative is shaped by their involvement with NMR facilities at Carnegie-Mellon University, Purdue University, and the University of Wisconsin-Madison.
• This perspective offers insights into the historical development and growth of the biomolecular NMR field.

Observation:

• The evolution of biomolecular NMR technology is detailed through personal experiences.
• The establishment and utilization of NMR facilities for biomedical studies are discussed.
• The authors' engagement with the Biological Magnetic Resonance data Bank (BMRB) and the Worldwide Protein Data Bank (wwPDB) is highlighted.

Findings:

• The trajectory of change in biomolecular NMR over several decades is illustrated.
• The development and accessibility of NMR technology for researchers have been central themes.
• The collaborative efforts and contributions of various groups to the field are acknowledged.

Implications:

• The historical perspective provides context for understanding current advancements in biomolecular NMR.
• Anticipation of future unexpected advances suggests continued innovation in the field.
• The narrative underscores the importance of dedicated facilities and data banks in advancing scientific discovery.