Related Experiment Video
Updated: Mar 2, 2026
10:40
Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
Published on: December 5, 2025
84.8K
Extracellular Vesicles in Metabolic Syndrome
M Carmen Martínez1, Ramaroson Andriantsitohaina2
1From the INSERM UMR 1063 Stress oxydant et pathologies métaboliques, UNIV Angers, Université Bretagne Loire, France.
Circulation Research
|May 13, 2017
Summary
Extracellular vesicles (EVs) are key in cell communication and show potential as biomarkers for metabolic syndrome. Research explores their role in disease pathways and as therapeutic targets.
Area of Science:
- Cell Biology
- Biochemistry
- Endocrinology
Background:
- Metabolic syndrome involves risk factors like hyperglycemia, obesity, and hypertension.
- Extracellular vesicles (EVs) mediate cell-to-cell communication, carrying proteins, lipids, and genetic material.
- EVs are implicated in physiological and pathological processes, including metabolic diseases.
Purpose of the Study:
- To review the role of extracellular vesicles (EVs) in metabolic syndrome.
- To explore EVs as potential biomarkers and therapeutic targets for metabolic syndrome.
- To elucidate disease-specific pathways involving EVs in metabolic disorders.
Main Methods:
- Literature review of recent data on EVs from various cell origins.
- Analysis of EV composition, function, and circulating levels in metabolic syndrome.
- Examination of EV-mediated intercellular communication in metabolic disease.
Main Results:
- Circulating levels of EVs are elevated in metabolic syndrome patients.
- EVs from diverse origins (endothelial cells, adipocytes, microbiota, etc.) contribute to metabolic syndrome.
- EVs contain specific markers, enabling monitoring in circulation.
Conclusions:
- Extracellular vesicles (EVs) are promising biomarkers for metabolic syndrome.
- EVs represent potential targets for novel therapeutic strategies.
- Understanding EV complexity is crucial for their application in diagnostics and therapeutics.
More Related Videos
07:03Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
2.7K
04:54Author Spotlight: Standardizing and Improving the Extraction and Purification of Extracellular Vesicles from Human ADSCs
Published on: May 3, 2024
1.3K
Related Concept Videos
01:36Overview of Exosomes
3.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.8K
01:33Overview of Secretory Vesicles
9.7K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.7K
01:38Intralumenal Vesicles and Multivesicular Bodies
5.0K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.0K
01:05Insulin Secretory Vesicles
7.2K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
7.2K
01:29Cholesterol: Significance and Regulation
1.7K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.7K
01:45Vesicular Tubular Clusters
3.3K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
With the help of motor proteins such...
3.3K