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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Stimuli-Responsive Polymeric Nanoparticles.

Xiaolin Liu1, Ying Yang1, Marek W Urban1

  • 1Department of Materials Science and Engineering, Clemson University, Clemson, SC, 29634, USA.

Macromolecular Rapid Communications
|May 13, 2017
PubMed
Summary
This summary is machine-generated.

Stimuli-responsive nanomaterials are crucial for technological advancements. This review covers the synthesis and surface modification of these advanced nanoparticles, detailing their diverse morphologies and responsive behaviors.

Keywords:
colloidsmorphologynanoparticlesstimuli-responsivenesssurface modification

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Stimuli-responsive nanomaterials are increasingly vital for modern technological applications.
  • Advances in nanoparticle synthesis and surface modification are driving innovation.

Purpose of the Study:

  • To review recent progress in stimuli-responsive polymeric nanoparticles (Part A) and surface-modified functional nanoparticles (Part B).
  • To highlight the synthesis, fabrication, and diverse morphologies of these responsive nanomaterials.
  • To explore opportunities for novel synthetic approaches and hybrid organic-inorganic nanostructures.

Main Methods:

  • Discussion of synthesis and construction of various stimuli-responsive nanoparticle morphologies (spherical, core-shell, hollow, etc.).
  • Focus on shape, color, or size changes induced by external stimuli.
  • Analysis of surface modification techniques, including grafting-to and grafting-from methods.

Main Results:

  • Detailed overview of stimuli-responsive polymeric nanoparticle fabrication.
  • Exploration of surface functionalization strategies for enhanced nanoparticle responsiveness.
  • Introduction of novel hybrid nanostructures like 'ceramers' and 'metamers'.

Conclusions:

  • Stimuli-responsive nanomaterials offer significant potential for advanced applications.
  • Surface modification plays a key role in tailoring nanoparticle responsiveness.
  • Hybrid organic-inorganic nanostructures present exciting avenues for future materials design.