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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Colistin use in critically ill neonates: A case-control study.

Mehmet Sah İpek¹, Fesih Aktar², Nilufer Okur³

¹Division of Neonatology, Department of Pediatrics, Memorial Dicle Hospital, Diyarbakir, Turkey.

Pediatrics and Neonatology

|May 15, 2017

Summary

Colistin is safe and effective for treating multidrug-resistant bacterial infections in newborns. However, intravenous colistin use is linked to lower magnesium and potassium levels.

Keywords:

colistin gram-negative bacteria multi-drug resistant neonate nosocomial infection

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Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

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Area of Science:

Neonatalogy
Infectious Diseases
Pharmacology

Background:

Neonatal infections pose a significant threat, especially those caused by multidrug-resistant organisms.
Colistin is a critical antibiotic for treating infections resistant to other drugs.
Assessing colistin's safety and efficacy in vulnerable neonatal populations is crucial.

Purpose of the Study:

To evaluate the safety and effectiveness of colistin in critically ill neonates.
To compare outcomes of colistin therapy versus other antimicrobials in neonates.

Main Methods:

A case-control study was conducted in two Turkish centers from January 2012 to October 2015.
Included were newborn infants with proven or suspected nosocomial infections.
Colistin recipients were compared to neonates treated with alternative antibiotics.

Main Results:

Forty-seven neonates received intravenous colistin, and 59 controls received other antibiotics.
No significant differences in overall outcomes or nephrotoxicity (acute renal failure) were observed.
Colistin therapy was associated with reduced serum magnesium and increased hypokalemia, longer hospital stays, and higher rates of prior carbapenem exposure.

Conclusions:

Colistin demonstrates efficacy and safety for treating neonatal infections caused by multidrug-resistant gram-negative bacteria.
Intravenous colistin use in neonates is significantly associated with hypomagnesemia and hypokalemia.
Careful monitoring of electrolytes is recommended during colistin treatment in neonates.