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Related Experiment Video

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Surface engineering for lymphocyte programming.

Elana Ben-Akiva1, Randall A Meyer2, David R Wilson2

  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Advanced Drug Delivery Reviews
|May 15, 2017
PubMed
Summary
This summary is machine-generated.

Immunoengineering uses engineered surfaces to control immune cells like T-cells and B-cells for disease treatment. These advanced biomaterial strategies are crucial for developing new cancer and infectious disease therapies.

Keywords:
Artificial antigen presenting cellLymphocyte engineeringMicroparticleNanoparticle

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Area of Science:

  • Immunoengineering
  • Biomaterials Science
  • Immunology

Background:

  • The field of immunoengineering has advanced significantly, focusing on programming lymphocytes to combat diseases.
  • Recent progress builds on understanding lymphocyte activation mechanics at molecular and physical levels.

Purpose of the Study:

  • To explore strategies for engineering surfaces to modulate T-cell, B-cell, and natural killer cell activity.
  • To review advancements in designing biomaterials for targeted immune responses.

Main Methods:

  • Engineering surfaces at the molecular level by controlling biomolecule presence, arrangement, and diffusivity.
  • Tuning physical and mechanical surface characteristics like shape, anisotropy, and rigidity for lymphocyte activation.
  • Developing acellular systems for cell expansion and programming.

Main Results:

  • Engineered surfaces can elicit specific lymphocyte fates, activating or deactivating key immune cells.
  • Acellular systems have been successfully developed for expanding T-cells and natural killer cells for cancer therapy.
  • Engineered B-cell programming shows promise for enhancing responses against infectious diseases.

Conclusions:

  • Surface engineering in immunoengineering offers versatile strategies for therapeutic applications.
  • These advancements are critical for developing novel treatments for cancer and infectious diseases.
  • Further preclinical and clinical development is ongoing for these engineered immuno-approaches.