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Related Experiment Videos

Alpha 1-adrenoceptor desensitisation.

C A Hamilton1, J L Reid

  • 1University Department of Materia Medica, Stobhill General Hospital, Glasgow, U.K.

European Journal of Pharmacology
|July 26, 1988
PubMed
Summary
This summary is machine-generated.

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Intravenous phenylephrine infusions did not significantly reduce pressor responses in rabbits. Alpha 1-adrenoceptors show resistance to in vivo agonist desensitization, unlike alpha 2- and beta-adrenoceptors.

Area of Science:

  • Pharmacology
  • Adrenoceptor Physiology

Background:

  • Adrenoceptors mediate physiological responses to catecholamines.
  • Agonist-induced receptor desensitization is a key regulatory mechanism.

Purpose of the Study:

  • To investigate the in vivo desensitization of alpha 1-adrenoceptors.
  • To compare the desensitization of alpha 1-adrenoceptors to alpha 2- and beta-adrenoceptors.

Main Methods:

  • Conscious rabbits received intravenous infusions of phenylephrine.
  • Pressor responses to bolus phenylephrine doses were measured.
  • Phenoxybenzamine was used to block alpha 1-adrenoceptor reserve.

Main Results:

  • Four-hour phenylephrine infusions failed to attenuate pressor responses.

Related Experiment Videos

  • Attenuation was observed only after alpha 1-adrenoceptor blockade with phenoxybenzamine.
  • High phenylephrine doses required for desensitization were poorly tolerated.

    • Conclusions:

    • Rabbit vascular smooth muscle alpha 1-adrenoceptors are resistant to in vivo agonist desensitization.
    • This resistance is greater compared to alpha 2- and beta-adrenoceptors.