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GABAB receptor activation inhibits 5-hydroxytryptamine-stimulated inositol phospholipid turnover in mouse cerebral
P P Godfrey1, D G Grahame-Smith, J A Gray
1University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, U.K.
European Journal of Pharmacology
|July 26, 1988
Abstract:
The effects of GABA agonists on inositol phospholipid metabolism were investigated in mouse cerebral cortex. GABA (in the presence of 1 mM nipecotic acid) dose dependently inhibited 5-hydroxytryptamine (5-HT)-stimulated [3H]inositol phosphate formation; maximal inhibition 60.4 +/- 8.8%, ED50 200 nM. The GABAB agonist baclofen had a similar effect; maximal inhibition 41.7 +/- 4.5%, ED50 100 nM. The inhibitory action of GABA was not blocked by bicucculine. The results suggest that GABAB receptors may modulate 5-HT2 receptor function at the level of signal transduction.