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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Eosinophilic Gastrointestinal Disorders.

Lisa M Fahey1, Chris A Liacouras1

  • 1Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, 7NW, Philadelphia, PA 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

Pediatric Clinics of North America
|May 16, 2017
PubMed
Summary
This summary is machine-generated.

Eosinophilic esophagitis (EoE) is an allergic condition causing eosinophil buildup in the esophagus. Diagnosis requires endoscopy and biopsy after proton pump inhibitor treatment.

Keywords:
Eosinophilic esophagitisEosinophilic gastroenteritisEosinophilic proctocolitisFood allergensProton pump inhibitor-responsive esophageal eosinophilia

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Area of Science:

  • Gastroenterology
  • Allergy Immunology

Background:

  • Eosinophilic esophagitis (EoE) is an atopic disease.
  • It involves eosinophil infiltration into the esophageal epithelium.
  • Specific allergens trigger EoE.

Purpose of the Study:

  • To define the diagnostic criteria for EoE.
  • To differentiate EoE from other eosinophilic gastrointestinal disorders.

Main Methods:

  • Diagnosis of EoE requires upper endoscopy with biopsy.
  • Biopsy is performed after 6 to 8 weeks of proton pump inhibitor treatment.

Main Results:

  • EoE is characterized by isolated eosinophil infiltration in the esophagus.
  • Eosinophilic gastroenteritis involves eosinophils in any part of the GI tract.
  • Eosinophilic proctocolitis is limited to eosinophil infiltration in the colon.

Conclusions:

  • Proton pump inhibitor treatment followed by endoscopy and biopsy is crucial for EoE diagnosis.
  • Understanding the distribution of eosinophilic infiltration is key to diagnosing specific conditions like EoE, eosinophilic gastroenteritis, and eosinophilic proctocolitis.