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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Thromboelastometry and Thrombelastography Analysis under Normal Physiological Conditions - Systematic Review.

Marcel Adler¹, Sandra Ivic², Nicolas S Bodmer²

¹Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, and Department of Clinical Research, University of Bern, Bern, Switzerland.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie

|May 16, 2017

Summary

Research on thromboelastometry (ROTEM®) and thromboelastography (TEG®) in healthy individuals is limited. These hemostasis tests show weak correlations with conventional coagulation parameters, indicating a need for further investigation.

Keywords:

Healthy subjects Hemostasis Technical efficacy Thrombelastography Thromboelastometry

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Area of Science:

Hemostasis and Thrombosis Research
Clinical Laboratory Science

Background:

Thromboelastometry (ROTEM®) and thromboelastography (TEG®) are valuable diagnostic tools.
Existing research on these methods in physiological contexts is fragmented and difficult to access.
A systematic review is needed to consolidate findings on ROTEM® and TEG® in healthy subjects.

Purpose of the Study:

To systematically review and synthesize published data on ROTEM® and TEG® in healthy individuals.
To investigate the correlation between ROTEM®/TEG® measurements and conventional hemostasis parameters.
To identify gaps in current knowledge regarding these viscoelastic hemostasis assays.

Main Methods:

Systematic literature search across Medline, Scopus, and Science Citation Index.
Screening of reference lists from relevant studies and reviews.
Inclusion criteria focused on studies reporting ROTEM® or TEG® data in healthy subjects.
Data extraction by two independent reviewers.

Main Results:

Analysis of 8 studies involving 632 healthy subjects.
Limited investigation into the association between conventional hemostasis parameters and ROTEM®/TEG®.
Observed correlations were generally weak, ranging from 0.0 to 0.40.

Conclusions:

Published research correlating thromboelastometry/thromboelastography with conventional hemostasis parameters in healthy individuals is scarce.
The observed correlations are limited, suggesting incomplete understanding of these assays' physiological underpinnings.
Further research is essential to elucidate the full physiological relevance of ROTEM® and TEG® parameters.