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Related Experiment Video

Updated: Mar 2, 2026

A Protocol for Real-time 3D Single Particle Tracking
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Maximizing particle concentration in deterministic lateral displacement arrays.

Shilun L Feng, Alison M Skelley1, Ayad G Anwer

  • 1GPB Scientific LLC, 800 East Leigh St., Richmond, Virginia 23219, USA.

Biomicrofluidics
|May 16, 2017
PubMed
Summary

This study enhances deterministic lateral displacement arrays for superior particle concentration. The improved design concentrates particles into a central channel, achieving significant enrichment for micro-spheres and cells.

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Biophysics

Background:

  • Deterministic lateral displacement (DLD) arrays are microfluidic devices used for particle separation.
  • Previous DLD designs had limitations in achieving high particle concentration enhancement.
  • Understanding flow patterns is crucial for optimizing DLD device performance.

Purpose of the Study:

  • To improve deterministic lateral displacement arrays for higher particle concentration enhancement.
  • To correct and extend existing equations for mirror-symmetric boundaries in DLD devices.
  • To experimentally measure flow patterns and evaluate device performance with micro-spheres and cells.

Main Methods:

  • Modification of DLD array design with mirror-symmetric boundaries.

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  • Theoretical correction and extension of DLD equations.
  • Experimental measurement of flow patterns using microfluidic visualization.
  • Testing the device with hard micro-spheres and Jurkat cells.

    • Main Results:

    • Achieved higher particle concentration enhancement compared to previous methods.
    • Experimental flow patterns showed deviations from theoretical models.
    • Demonstrated 11-fold enrichment for 7 μm particles.
    • Achieved over 50-fold enrichment for 10 μm particles and Jurkat cells.

    Conclusions:

    • The enhanced DLD array design offers a clear pathway to unprecedented particle concentration.
    • Experimental validation confirmed the potential of the improved DLD system.
    • Further research into flow pattern discrepancies could lead to even greater optimization.