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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Emerging treatments for ulcerative colitis: a systematic review.
Damianos G Kokkinidis1,2, Eftychia E Bosdelekidou2,3, Sotiria Maria Iliopoulou2,4
1a Department of Medicine , Jacobi Medical Center, Albert Einstein College of Medicine , Bronx , NY , USA.
Novel ulcerative colitis (UC) treatments show promise. Vedolizumab, golimumab, and etrolizumab demonstrated superiority over placebo, offering new therapeutic options for UC patients.
Area of Science:
- Gastroenterology
- Pharmacology
- Clinical Medicine
Background:
- Ulcerative colitis (UC) management involves various investigational medicinal products.
- A systematic evaluation of novel pharmacological agents for UC is crucial.
Purpose of the Study:
- To systematically evaluate novel pharmacological therapeutic agents for ulcerative colitis (UC).
Main Methods:
- Systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
- MEDLINE literature search for original research papers published between January 1, 2010, and October 31, 2014.
Main Results:
- Analysis of 21 studies involving 11,524 adults identified 13 novel drug options.
- Vedolizumab, golimumab, and etrolizumab showed superiority over placebo in induction and/or maintenance therapy.
- Tofacitinib demonstrated dose-related efficacy; phosphatidylcholine improved clinical activity index; HMPL-004 may be a mesalamine alternative for mild-to-moderate UC.
Conclusions:
- Certain novel agents may offer clinical response or remission in UC patients with favorable side effect profiles.
- Further research is necessary to ascertain the short- and long-term efficacy and safety of these agents.
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