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Related Concept Videos

Sample Preparation for Analysis: Overview01:21

Sample Preparation for Analysis: Overview

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Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
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Related Experiment Video

Updated: Mar 2, 2026

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry
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Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

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Saliva: a reliable sample matrix in bioanalytics.

Michael Gröschl1

  • 1Celerion Switzerland AG, Allmendstrasse 32, CH-8320 Fehraltorf, Switzerland.

Bioanalysis
|May 16, 2017
PubMed
Summary
This summary is machine-generated.

Saliva analysis offers a noninvasive method for various scientific fields. This review details saliva

Keywords:
bioanalyticsendocrinologyforensicsimmunologynoninvasivesalivasports medicine

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Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles
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Collection and Extraction of Saliva DNA for Next Generation Sequencing
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Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry
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Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles
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Collection and Extraction of Saliva DNA for Next Generation Sequencing
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Area of Science:

  • Biochemistry
  • Physiology
  • Analytical Chemistry

Background:

  • Saliva is an increasingly utilized bioanalytical matrix due to its noninvasive collection.
  • Its ease of collection benefits endocrinology, behavioral science, and pediatrics.
  • Saliva is unique as it can be collected during physical exercise, offering advantages over serum or urine for specific research.

Purpose of the Study:

  • To provide insights into saliva formation physiology.
  • To explain compound entry into saliva.
  • To offer guidance on saliva collection, storage, and analytical techniques.

Main Methods:

  • Literature review of saliva physiology.
  • Analysis of compound transport mechanisms into saliva.
  • Compilation of best practices for sample handling and analysis.

Main Results:

  • Detailed explanation of saliva formation and analyte incorporation.
  • Recommendations for optimal saliva collection and storage protocols.
  • Overview of validated analytical methods for saliva.

Conclusions:

  • Saliva analysis is a versatile tool with proven applications in endocrinology, sports medicine, forensics, and immunology.
  • Understanding saliva physiology enhances the reliability of analytical results.
  • Standardized methods ensure the utility of saliva as a biofluid for scientific inquiry.