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Updated: Mar 2, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Pediatric corneal transplants.

Danielle Trief¹, Maria C Marquezan, Christopher J Rapuano

¹aDepartment of Ophthalmology, Columbia University Medical Center, New York, New York, USA bDepartment of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo, UNIFESP, Sao Paulo, Sao Paulo, Brazil cCornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania dWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.

Current Opinion in Ophthalmology

|May 16, 2017

Summary

This summary is machine-generated.

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Recent advances in pediatric keratoplasty improve outcomes for children. New surgical techniques and multidisciplinary care enhance vision restoration and long-term graft survival in pediatric corneal transplantation.

Area of Science:

Ophthalmology
Pediatric Surgery
Corneal Disease

Background:

Pediatric keratoplasty presents unique clinical and surgical challenges.
Successful corneal transplantation can restore vision in children with severe eye conditions.

Purpose of the Study:

To provide an update on recent advancements in pediatric keratoplasty.
To highlight improved outcomes and surgical techniques for children undergoing corneal transplantation.

Main Methods:

Review of current surgical techniques including penetrating keratoplasty (PKP), lamellar surgery (endothelial keratoplasty, deep anterior lamellar keratoplasty), and keratoprosthesis.
Discussion of clinical management strategies and prognostic indicators.

Main Results:

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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

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Corneal Donor Tissue Preparation for Endothelial Keratoplasty

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An “All-laser” Endothelial Transplant

An “All-laser” Endothelial Transplant

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Children undergoing corneal transplants face higher risks of rejection, infection, and graft dehiscence compared to adults.
Surgical modifications in PKP enhance stabilization of pediatric eyes.
Lamellar surgery offers targeted treatment with potentially fewer complications.
Keratoprosthesis is a viable option when PKP success is unlikely.

Conclusions:

Advances in surgical techniques and clinical management are leading to better outcomes in pediatric keratoplasty.
Safer, more targeted surgical options are becoming available for challenging pediatric corneal diseases.
A multidisciplinary approach and long-term follow-up are crucial for successful transplantation and graft survival.