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Updated: Mar 2, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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MEK Retinopathy. Clinical case reports.

P Rocha Cabrera1, E Quijada Fumero1, M J Losada Castillo1

  • 1Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna (Tenerife), España.

Archivos De La Sociedad Espanola De Oftalmologia
|May 17, 2017
PubMed
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New melanoma treatments like cobimetinib and vemurafenib can cause MEK retinopathy, affecting retinal pigment epithelium and causing detachment. Close monitoring with optical coherence tomography is crucial for early detection and management.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Background:

  • Metastatic cutaneous melanoma requires advanced therapies.
  • Cobimetinib and vemurafenib are used in combination for melanoma treatment.
  • MEK retinopathy is a potential side effect of these therapies.

Observation:

  • Three clinical cases of MEK retinopathy were observed.
  • Retinal pigment epithelium alterations and neurosensory detachment were characteristic.
  • Visual acuity outcomes varied among the patients.

Findings:

  • MEK retinopathy presented with retinal pigment epithelium changes and neurosensory detachment.
  • Two patients maintained good vision, while one experienced significant bilateral detachment and vision loss.
  • The combination therapy is linked to these ocular alterations.
Keywords:
CobimetinibMEKMacularOCTRetinopathyRetinopatía

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Implications:

  • Ocular side effects necessitate vigilant monitoring in patients receiving these melanoma treatments.
  • Macular optical coherence tomography is essential for detecting and managing MEK retinopathy.
  • Understanding these risks aids in optimizing patient care and visual outcomes.