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An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
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Malaria and diabetes.

Sanjay Kalra1, Deepak Khandelwal2, Rajiv Singla3

  • 1Department of Endocrinology, BRIDE, Karnal, India.

JPMA. the Journal of the Pakistan Medical Association
|May 17, 2017
PubMed
Summary
This summary is machine-generated.

Malaria is more common in people with diabetes, and managing malaria during pregnancy may prevent diabetes. Further research into the diabetes-malaria link and metformin

Keywords:
Malaria, Diabetes, Hypoglycemia, Ketosis, Mortality, Morbidity, Plasmodium, Metformin.

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Area of Science:

  • Global Health
  • Infectious Diseases
  • Endocrinology

Background:

  • Malaria and diabetes are significant public health issues, particularly in developing nations.
  • The direct relationship between malaria and diabetes has not been extensively studied.
  • Existing literature suggests a higher prevalence of malaria in individuals with diabetes.

Purpose of the Study:

  • To review and assess the existing literature on the relationship between malaria and diabetes.
  • To propose a pragmatic management approach for patients with both conditions.
  • To identify areas for future research concerning the interplay between malaria and diabetes.

Main Methods:

  • Comprehensive literature search using PubMed, Medline, and Embase databases.
  • Inclusion of articles published up to October 2016.
  • Manual searching of reference lists from identified articles, irrespective of language.

Main Results:

  • Studies indicate a higher incidence of malaria in diabetic populations, especially in Africa.
  • Malarial infections in pregnancy may contribute to the development of diabetes later in life.
  • Diabetic patients exhibit atypical malaria symptoms, and metformin shows potential antimalarial properties.

Conclusions:

  • Preventing and managing malaria in pregnant women could be a primary strategy for diabetes prevention.
  • The potential for a synergistic relationship between diabetes and malaria in humans warrants investigation.
  • Metformin's antimalarial effects suggest its potential use in malaria prevention and requires further evaluation.