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TIE-2 expressing monocytes in human cancers.

Riccardo Turrini1, Angélique Pabois1, Ioannis Xenarios2

  • 1Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland.

Oncoimmunology
|May 17, 2017
PubMed
Summary

TIE-2 expressing monocytes (TEM) are a newly identified subset of immune cells that promote tumor growth and angiogenesis. Targeting TEM offers a promising therapeutic strategy for human cancers.

Keywords:
Human cancerTEMTIE-2-expressing monocytesmonocytestumor microenvironment

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Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Tumor-associated macrophages (TAM) are crucial in the tumor microenvironment, supporting cancer progression.
  • A specific monocyte subset expressing the TIE-2/Tek receptor exhibits proangiogenic activity.

Purpose of the Study:

  • To review the phenotypes and functions of TIE-2 expressing monocytes (TEM) in human cancer.
  • To explore the potential of TEM as biomarkers for cancer progression and metastasis.
  • To discuss therapeutic strategies targeting TEM.

Main Methods:

  • Literature review of studies on TEM in human cancer.
  • Analysis of TEM phenotypes and functions.
  • Evaluation of therapeutic approaches targeting TEM.

Main Results:

  • TIE-2 expressing monocytes (TEM) are found in both circulation and tumor tissues in humans and mice.
  • TEM possess proangiogenic properties, contributing to tumor growth.
  • TEM show potential as predictive markers for cancer progression and metastasis.

Conclusions:

  • TEM represent a significant cellular component within the tumor microenvironment.
  • Understanding TEM biology is crucial for developing novel cancer therapies.
  • Targeting TEM may offer a new avenue for cancer treatment and management.