Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

63
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
63
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

54
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
54
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

105
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
105
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

58
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
58
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

55
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
55
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

51
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
51

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Extent Of Gender/Sex Variables Included In Clinical Algorithms Across Medical Specialties.

Health affairs (Project Hope)·2026
Same author

Declarations of Independence - Physicians and the U.S. Body Politic, 1776-2026.

The New England journal of medicine·2026
Same author

Prescription without Precision - Dangers of Dosing on the Basis of Race as Biology.

The New England journal of medicine·2026
Same author

A Eulogy for Structural Competence?

The New England journal of medicine·2026
Same author

The Rise, Fall, and Laser Resurrection of the "Snake Heart" Operation.

Journal of the history of medicine and allied sciences·2026
Same author

On a heating planet, do humans and corals face a shared risk?

Lancet (London, England)·2026

Related Experiment Video

Updated: Mar 2, 2026

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

8.8K

Photochemically Controlled Drug Dosing from a Polymeric Scaffold.

Louise Donnelly1, John G Hardy1, Sean P Gorman1

  • 1School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, BT9 7BL, UK.

Pharmaceutical Research
|May 17, 2017
PubMed
Summary

Researchers developed a novel photoactive biomaterial coating for controlled drug release. This poly(2-methyoxyethyl acrylate) scaffold houses drug-DMB conjugates, enabling precise dosing via UV light activation.

Keywords:
Controlled drug releaseDosingHydrogelLightpMEA

More Related Videos

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

13.5K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.6K

Related Experiment Videos

Last Updated: Mar 2, 2026

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

8.8K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

13.5K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.6K

Area of Science:

  • Biomaterials Science
  • Photochemistry
  • Drug Delivery Systems

Background:

  • Controlled drug release is crucial for therapeutic efficacy.
  • Photoactive materials offer precise spatiotemporal control over drug delivery.
  • Poly(2-methyoxyethyl acrylate) (pMEA) is a versatile polymer scaffold.

Purpose of the Study:

  • To create the first photoactive biomaterial coating for controlled drug dosing.
  • To incorporate synthesized drug-3,5-dimethoxybenzoin (DMB) conjugates into a pMEA scaffold.
  • To investigate photo-controlled drug liberation from the biomaterial.

Main Methods:

  • Synthesis and characterization of flurbiprofen- and naproxen-DMB conjugates via esterification, NMR, and mass spectrometry.
  • Investigation of conjugate photolysis in solution and within the pMEA matrix using 365 nm UV irradiation.
  • Monitoring photo-drug liberation into phosphate-buffered saline using UV-Vis spectroscopy.

Main Results:

  • Successful synthesis and characterization of drug-DMB conjugates.
  • Demonstrated photo-liberation of drugs from the pMEA scaffold upon UV irradiation.
  • Achieved controlled drug release with multi-dosing capability, increasing dose with exposure time.

Conclusions:

  • This study presents the first photo-controlled drug release from a biomaterial coating.
  • The pMEA scaffold is feasible for housing photoactive drug-DMB conjugates.
  • This technology holds promise for advanced, targeted drug delivery applications.