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Sentinel Lymph Node Biopsy for Recurrent Melanoma: A Multicenter Study.

Georgia M Beasley1, Yinin Hu2, Linda Youngwirth3

  • 1Division of Surgical Oncology, Ohio State University Wexner Medical Center, Columbus, OH, USA. Georgia.beasley@osumc.edu.

Annals of Surgical Oncology
|May 17, 2017
PubMed
Summary
This summary is machine-generated.

Sentinel lymph node biopsy (SLNB) is effective for locally recurrent (LR) or in-transit (IT) melanoma, even after prior procedures. This approach aids in managing and predicting prognosis for melanoma patients with advanced disease.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatology

Background:

  • Sentinel lymph node biopsy (SLNB) is standard for primary cutaneous melanoma.
  • Limited data exist on SLNB for locally recurrent (LR) or in-transit (IT) melanoma.
  • Assessing SLNB in LR/IT melanoma is crucial for patient management.

Purpose of the Study:

  • Evaluate the success rate of SLNB in patients with LR/IT melanoma.
  • Determine the positivity rate of SLNB in this patient group.
  • Assess the prognostic value of SLNB for LR/IT melanoma.

Main Methods:

  • Retrospective review of SLNB data from three centers (1997-present).
  • Included 107 patients with LR or IT melanoma.
  • Analyzed SLNB success, positivity, and correlation with outcomes.

Main Results:

  • SLNB was successful in 96% of cases.
  • SLNB positivity rate was 40% (41/107 patients).
  • Positive SLNB correlated with shorter time to progression and a trend towards poorer survival.

Conclusions:

  • SLNB is a feasible and successful procedure for LR/IT melanoma, even with prior SLNB.
  • SLNB positivity (40%) and nonsentinel node metastasis (37%) rates are significant.
  • SLNB provides valuable prognostic information and guides management for LR/IT melanoma.