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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Repressible Operon: trp Operon01:21

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The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
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Transducer Mechanism: G Protein–Coupled Receptors01:30

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
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Enzyme-linked Receptors01:00

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Cotranslational Protein Translocation01:20

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Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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Related Experiment Video

Updated: Mar 2, 2026

Controllable Ion Channel Expression through Inducible Transient Transfection
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Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

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TRP Channel Classification.

Hongyu Li1

  • 1Columbia University Medical Center, New York, NY, 10032, USA. hl2880@cumc.columbia.edu.

Advances in Experimental Medicine and Biology
|May 17, 2017
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential (TRP) ion channels, activated by diverse stimuli, are crucial in physiology and pathology. This summary outlines the classification and functions of the TRP cation channel superfamily across species.

Keywords:
Ion channelTransient receptor potential (TRP) proteintrp gene

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Area of Science:

  • Molecular Biology
  • Physiology
  • Biochemistry

Background:

  • Transient Receptor Potential (TRP) ion channels are a superfamily of cation channels.
  • TRP channels are activated by a wide range of extracellular and intracellular stimuli.
  • They play significant roles in numerous physiological processes and diseases.

Purpose of the Study:

  • To summarize the classification of TRP ion channels.
  • To outline the diverse functions of TRP ion channels.
  • To provide an overview of the TRP cation channel superfamily.

Main Methods:

  • Literature review of TRP channel research.
  • Comparative analysis of TRP channel families across species.
  • Functional characterization of TRP channels.

Main Results:

  • Identified seven TRP families in mammals: TRPC, TRPV, TRPM, TRPA, TRPP, TRPML, and TRPN.
  • Reported the identification of an eighth TRP family, TRPY, in yeast.
  • Highlighted the diverse physiological and pathological roles of TRP channels.

Conclusions:

  • The TRP channel superfamily is evolutionarily conserved and functionally diverse.
  • Understanding TRP channel classification and function is vital for biomedical research.
  • TRP channels represent important targets for therapeutic interventions.