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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Updated: Mar 2, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Neuroproteomics Studies: Challenges and Updates.

Naify Ramadan¹, Hussein Ghazale¹, Mohammad El-Sayyad²

¹Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Methods in Molecular Biology (Clifton, N.J.)

|May 17, 2017

Summary

Neuroproteomics, a subdiscipline of proteomics, analyzes brain proteins to understand disorders and neurotrauma. This field is advancing biomarker research and injury mechanisms for translational applications.

Keywords:

High-throughput immunoblotting Human Genome Project Human Proteome Project (HPP)IMS Imaging mass spectrometry (MS)Neuroproteomics Proteomics

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Published on: April 10, 2014

Area of Science:

Neuroscience
Proteomics
Genomics

Background:

The Human Genome Project enabled the Human Proteome Project (HPP) for comprehensive protein map characterization.
Proteomics, a multidisciplinary field, studies protein changes under specific physiological conditions.
Neuroscience research benefits from proteomics, leading to the development of neuroproteomics.

Purpose of the Study:

To provide a historical perspective on neuroproteomics.
To highlight neuroproteomics applications in neurotrauma research.
To recommend advancing neuroproteomics as a mature scientific discipline.

Main Methods:

Review of historical development in neuroproteomics.
Analysis of current neuroproteomics applications in neurotrauma.
Discussion on the transition of neuroproteomics from a descriptive to a hypothesis-driven field.

Main Results:

Neuroproteomics aids in biomarker discovery for neurotrauma.
It elucidates spatiotemporal injury mechanisms in the brain.
Findings are being translated from experimental models to human applications.

Conclusions:

Neuroproteomics is crucial for understanding brain disorders and neurotrauma.
The field shows promise in biomarker research and mechanistic insights.
Further development is needed to establish neuroproteomics as a mature, independent scientific discipline.