Related Experiment Video
Updated: Mar 2, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Synthesis of Brominated Thiazoles via Sequential Bromination-Debromination Methods
Eric J Uzelac1, Seth C Rasmussen1
1Department of Chemistry and Biochemistry, North Dakota State University , NDSU Department 2735, P.O. Box 6050, Fargo, North Dakota 58108-6050, United States.
Abstract:
The synthesis of the full family of bromothiazoles has been revisited in order to update and optimize their production. The species reported include 2-bromothiazole, 4-bromothiazole, 5-bromothiazole, 2,4-dibromothiazole, 2,5-dibromothiazole, 4,5-dibromothiazole, and 2,4,5-tribromothiazole, the majority of which are produced via sequential bromination and debromination steps. This complete family can now be produced without the use of elemental bromine, and the presented methods have allowed the physical and NMR spectroscopic characterization of the full family to be reported for the first time.
More Related Videos
08:26Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route
Published on: April 3, 2016
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Related Concept Videos
Halogenation of Alkenes
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
Radical Substitution: Allylic Bromination
α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction
Reactions at the Benzylic Position: Halogenation
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Formation of Halohydrin from Alkenes