Related Experiment Video
Updated: Mar 2, 2026

Fabricating Multi-Component Lipid Nanotube Networks Using the Gliding Kinesin Motility Assay
Published on: July 26, 2021
The lipid network
Marc-Antoine Sani1, Frances Separovic2, John D Gehman2
1School of Chemistry, Bio21 Institute, University of Melbourne, Melbourne, VIC, 3010, Australia. msani@unimelb.edu.au.
Abstract:
Natural cell membranes are composed of a remarkable variety of lipids, which provide specific biophysical properties to support membrane protein function. An improved understanding of this complexity of membrane composition may also allow the design of membrane active drugs. Crafting a relevant model of a cell membrane with controlled composition is becoming an art, with the ability to reveal the molecular mechanisms of biological processes and lead to better treatment of pathologies. By matching physiological observations from in vivo experiments to high-resolution information, more easily obtained from in vitro studies, complex interactions at the lipid interface are determined. The role of the lipid network in biological membranes is, therefore, the subject of increasing attention.
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