Characterizing Cognitive Impairment in Parkinson's Disease
Meagan Bailey1, Jennifer G Goldman1
1Department of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Chicago, Illinois.
Seminars in Neurology
|May 17, 2017
Summary
Cognitive impairment in Parkinson's disease (PD) is diverse. Research now better defines PD dementia and mild cognitive impairment phenotypes, biomarkers, and treatments to manage cognitive decline.
Area of Science:
- Neurology
- Neuroscience
- Cognitive Science
Background:
- Cognitive impairment is a common and heterogeneous complication in Parkinson's disease (PD).
- Deficits vary in clinical presentation, severity, and progression toward dementia.
- Recent advances have improved diagnostic criteria and understanding of PD dementia and PD mild cognitive impairment.
Purpose of the Study:
- To summarize current research on cognitive impairment in Parkinson's disease.
- To focus on clinical phenotypes, neuropsychiatric and prodromal features.
- To review pathological changes, genetic variations, and biomarkers.
Main Methods:
- Literature review of current research on cognitive impairment in Parkinson's disease.
- Synthesis of findings related to clinical presentation, biomarkers, and pathophysiology.
- Focus on diagnostic criteria and therapeutic interventions.
Main Results:
- Cognitive impairment in PD presents heterogeneously, impacting clinical features, severity, and dementia progression.
- Advances in diagnostics and understanding of PD dementia and PD mild cognitive impairment phenotypes are noted.
- Research highlights associated neuropsychiatric features, prodromal symptoms, pathology, genetics, and imaging/biochemical biomarkers.
Conclusions:
- A comprehensive understanding of cognitive impairment in PD is crucial for effective management.
- Identifying specific phenotypes and biomarkers aids in early diagnosis and targeted therapies.
- Continued research into pathophysiology and genetics may lead to preventative strategies for cognitive decline in PD.
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