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Intense resistance exercise increases peripheral brain-derived neurotrophic factor.

Kieran J Marston1, Michael J Newton1, Belinda M Brown2

  • 1School of Psychology and Exercise Science, Murdoch University, Australia.

Journal of Science and Medicine in Sport
|May 18, 2017
PubMed
Summary
This summary is machine-generated.

Resistance exercise to fatigue, specifically hypertrophy training, effectively increases brain-derived neurotrophic factor (BDNF) levels. Lactate does not appear to drive this BDNF response in resistance exercise.

Keywords:
Alzheimer’s diseaseLactateMuscular fatigueNeurotrophinStrength training

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Area of Science:

  • Exercise Physiology
  • Neuroscience
  • Biochemistry

Background:

  • Aerobic exercise is known to increase brain-derived neurotrophic factor (BDNF) in an intensity-dependent manner.
  • Previous research on resistance exercise and BDNF levels has yielded inconclusive results, potentially due to the low intensity of traditional programs.

Purpose of the Study:

  • To investigate the impact of acute resistance exercise to-fatigue on serum BDNF levels.
  • To examine the relationship between serum BDNF and blood lactate levels following different resistance exercise protocols.

Main Methods:

  • An acute crossover study design was employed.
  • Eleven untrained to intermediately trained males and five females participated.
  • Participants completed two resistance exercise bouts to fatigue: strength (5x5 reps) and hypertrophy (3x10 reps), with measurements taken immediately and 30 minutes post-exercise.

Main Results:

  • Hypertrophy-based resistance exercise resulted in significantly higher serum BDNF levels compared to strength-based exercise immediately post-exercise.
  • A positive correlation was found between changes in lactate and BDNF levels post-exercise following hypertrophy training.
  • No significant correlation between lactate and BDNF changes was observed following strength training.

Conclusions:

  • A hypertrophy-focused resistance exercise protocol performed to fatigue is effective in stimulating an increase in peripheral serum BDNF.
  • The study suggests that lactate accumulation may not be the primary mechanism driving BDNF elevation during resistance exercise.