[An immunosorbent method for the quantitative determination of antiliver autoantibodies in patients with viral...

Autoimmune processes in patients with mild, moderate and severe forms of viral hepatitis B have been studied with the use of a new immunosorbent method for the quantitative determination of autoantibodies (auto-Ab), developed by the authors. The immunosorbent has been obtained on the basis of granulated aerosil, an active protein-adsorbent agent used as a solid antigen carrier. The level of auto-Ab in patients with all forms of viral hepatitis B has been found to exceed the content of such antibodies in practically healthy persons. Besides, in patients with severe and prolonged forms of the disease the content of antihepatic auto-Ab has been found to remain high even after clinical convalescence, which is indicative of the continuation of the autoimmune process.