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Acoustophoretic Mobility and Its Role in Optimizing Acoustofluidic Separations.

Philip Stephen Williams1, Michel Martin2, Mauricio Hoyos2

  • 1Cambrian Technologies Inc. , 1772 Saratoga Avenue, Cleveland, Ohio 44109, United States.

Analytical Chemistry
|May 18, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a quantitative theory for acoustic split-flow thin channel (SPLITT) fractionation, optimizing continuous separation of non-Brownian materials. The work defines acoustophoretic mobility, advancing acoustofluidic separation techniques.

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Area of Science:

  • Separation science
  • Fluid dynamics
  • Acoustics

Background:

  • Separation science relies on physicochemical properties and selective fields.
  • Continuous separations can be achieved using microfluidic or split-flow thin channel (SPLITT) devices.
  • Species are separated based on differential mobility within a fluid under an applied field.

Purpose of the Study:

  • To present the theory for optimizing acoustic SPLITT fractionation for continuous separation of non-Brownian materials.
  • To quantitatively define acoustophoretic mobility for advancing acoustofluidic separations.

Main Methods:

  • Development of a quantitative theory for acoustic SPLITT fractionation.
  • Consistent definition of acoustophoretic mobility with Giddings' generalized mobility concept.

Main Results:

  • A quantitatively defined acoustophoretic mobility is presented.
  • The theory provides a framework for optimizing acoustic SPLITT fractionation operations.

Conclusions:

  • The quantitative definition of acoustophoretic mobility is crucial for the advancement of acoustofluidic separations.
  • This theoretical framework enhances the continuous separation capabilities of acoustic SPLITT devices for non-Brownian materials.