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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Hypertensive disorders of pregnancy increase the risk for chronic kidney disease: A population-based retrospective

Maika Oishi1, Kaori Iino1, Kanji Tanaka1

  • 1a Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine , Hirosaki , Japan.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|May 18, 2017
PubMed

Insights

Women with hypertensive disorders of pregnancy (HDP) face a significantly higher risk of developing chronic kidney disease (CKD) later in life. Early awareness can empower women to prevent future kidney and cardiovascular diseases.

Area of Science:

  • Nephrology
  • Obstetrics
  • Cardiology

Background:

  • Hypertensive disorders of pregnancy (HDP) and chronic kidney disease (CKD) are established risk factors for later-life cardiovascular disease (CVD).
  • Limited research exists on the association between HDP and CKD, particularly using data that includes subclinical CKD.
  • Existing studies often rely on registry or clinical data, not population-based records.

Purpose of the Study:

  • To investigate the relationship between HDP and CKD diagnosed by estimated glomerular filtration rate (eGFR) in later life.
  • To address the gap in understanding HDP's impact on long-term kidney health.
  • To assess the risk of CKD in women with a history of HDP.

Main Methods:

  • Population-based, retrospective study design.
  • Review of blood, physiological, and pregnancy data from 312 women's Maternity Health Record Books.
  • Diagnosis of CKD based on eGFR.

Main Results:

  • A history of HDP was significantly associated with an increased risk of CKD in later life (OR: 4.854, 95% CI: 1.042-22.621).
  • Hypertension at the time of examination was also significantly linked to CKD (OR: 3.109, 95% CI: 1.213-11.510).
  • 15 women were diagnosed with CKD and 14 with HDP.

Conclusions:

  • HDP is a significant risk factor for developing CKD later in life.
  • Early recognition of CKD and CVD risks associated with HDP is crucial for preventative strategies.
  • Promoting awareness among women about these risks can facilitate timely interventions.

Keywords:
Cardiovascular diseaseMaternity Health Record Bookchronic kidney diseasehypertensionhypertensive disorders of pregnancy

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