Radiologic-Pathologic Correlation: Acellular Dermal Matrix (Alloderm^®) Used in Breast Reconstructive Surgery

Acellular dermal matrix (ADM) such as Alloderm^® is sometimes used in tissue reconstruction in primary and reconstructive breast surgeries. As ADM is incorporated into the native tissues, the evolving imaging findings that would correlate with varying degrees of host migration and neoangiogenesis into the matrix can be challenging to recognize. In the setting of a palpable or clinical area of concern after breast reconstructive surgery following breast cancer, confident diagnosis of a mass representing ADM rather than recurring or developing disease can be challenging. Such diagnostic imaging uncertainties generally result in short-term imaging and clinical follow-up, but occasionally, biopsy is performed for histopathological confirmation of benignity. A case of biopsy-proven Alloderm^® is described. To the best of our knowledge, this is the first radiologic-pathologic correlation of ADM in the literature.