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Analysis of phase error effects in multishot diffusion-prepared turbo spin echo imaging.

Anh T Van1, Barbara Cervantes2, Hendrik Kooijman3

  • 1Zentralinstitut für Medizintechnik, Technical University of Munich, Garching, Germany.

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|May 19, 2017
PubMed
Summary

Phase errors in diffusion-prepared turbo spin echo (dprep-TSE) MRI affect signal magnitude and phase. Magnitude stabilizers remove magnitude modulation, but phase inconsistencies require resolution in multi-shot dprep-TSE.

Keywords:
Diffusion-prepared turbo spin echo (dprep-TSE)body diffusioneddy currentsflow-compensationmotion-induced phase errors (MiPe)

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Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Signal Processing

Background:

  • Diffusion-prepared turbo spin echo (dprep-TSE) sequences are susceptible to phase errors.
  • Phase errors impact both the magnitude and phase of the diffusion-weighted (DW) signal.

Purpose of the Study:

  • To characterize the effects of phase errors on DW signal magnitude and phase in dprep-TSE.
  • To evaluate methods for mitigating phase error artifacts.

Main Methods:

  • Derived an analytical expression for phase error effects.
  • Verified findings using Bloch simulations, phantom, and in vivo experiments.
  • Investigated motion and eddy currents as primary phase error sources.

Main Results:

  • Phase errors cause signal magnitude and phase modulation in dprep-TSE data.
  • Conventional methods fail to eliminate eddy-current-induced magnitude modulation after motion compensation.
  • Magnitude stabilizers effectively remove magnitude modulation but not phase modulation.
  • Motion-induced phase errors (MiPe) must be addressed in multi-shot dprep-TSE.

Conclusions:

  • Magnitude stabilizers are essential for correcting phase error-induced magnitude modulation in dprep-TSE.
  • Inconsistent phase modulation across shots in multi-shot dprep-TSE requires pre-combination resolution.